Neurogenerative diseases
Polysaccharide-based nanoparticles are emerging as promising immunomodulatory compounds. They are of increasing interest to researchers exploring potential treatments for neurodegenerative diseases.
A new review paper provides a comprehensive analysis of polysaccharide‐based nanoparticles in the context of three major neurodegenerative diseases: Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
The review notes that fucoidans have previously been shown to block lymphocyte adhesion, inhibit enzymes and induce apoptosis. Their primary mechanism of action is reported to be the downregulation of MAPK and NF‐κβ signalling pathways, thereby reducing pro‐inflammatory cytokine production.
The authors focused on the structural, chemical and biological characteristics of fucoidans and other polysaccharides, exploring their potential roles in targeting neuroinflammation and neurodegeneration.
Detailed findings are available in the paper, ‘Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases’, published in Ibrain.